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Key Reviews

Lam, I,  Hallacli, E,  and Khurana, V. Proteome-scale mapping of perturbed proteostasis in living cells.  Cold Spring Harbor Persp Biol 2019 Mar 25. pii: a034124. doi: 10.1101/cshperspect.a034124. PDF

Jarosz, DF and Khurana, V Specification of Physiologic and Disease States by Distinct Proteins and Protein Conformations. Cell. 2017 Nov 16; 171(5):1001-1014. PDF

Khurana, V, Tardiff, DF, Chung, CY, & Lindquist, S. Toward stem cell-based phenotypic screens for neurodegenerative diseases. Nature Reviews Neurology 2015 11(6):339-50. PDF

Khurana V and Lindquist S. Modeling neurodegeneration in S. cerevesiae: Why cook with baker’s yeast? Nature Reviews Neuroscience 2010 11(6):436-49. PDF

Alpha-synuclein

Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR. ß2-Adrenoreceptor is a regulator of the a-synuclein gene driving risk of Parkinson’s disease. Science. 2017 09 01; 357(6354):891-898. PDF

Khurana V*º, Chung CY*, Peng J*, Auluck PK, Tardiff DF, Fanning S, Bartels T, Koeva M, Benyamini   H, Lou Y, Nutter-Upham A, Tuncbag N, Baru V, Freyzon Y, Costanzo M, San-Luis B, Schöndorf DC, Barrasa MI, Caraveo G, Ehsani S, Sanjana N, Zhong Q, Gasser T, Vidal M, Deleidi M, Boone C, Berger Bº, Fraenkel Eº, Lindquist S. Genome-scale molecular networks link neurodegenerative disease genes to alpha-synuclein through specific molecular pathways. Cell Systems 2017 4(2): 157-70. PDF  *Equal contribution ºCo-corresponding authors

Chung CY*º, Khurana V*º, Loh K, Yi S, Sahni N, Hill D, Peng J, Vidal M, Ting A, Lindquist S. In situ proteome approaches connect alpha-synuclein directly to endocytic trafficking and mRNA metabolism. Cell Systems 2017 4(2): 242-250. PDF *Equal contribution ºCo-corresponding authors

Chung CY*, Khurana V*, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast A, Muffat J, Mitalipova M, Pluth MD, Jui NT, Schüle B, Lippard SJ, Tsai LH, Krainc D, Buchwald, SL, Jaenisch R, Lindquist S. Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science 2013 342 (6161): 983-87. PDF *Equal contribution

Tardiff DF, Jui NT, Khurana V, Tambe M, Tucci ML, Chung CY, Lancaster AK, Caldwell KA, Caldwell GA, Rochet JC, Buchwald ST, Lindquist S. Phenotypic screening and chemical genetics reveals a “druggable” Rsp5/Nedd4 network that ameliorates αsynuclein toxicity. Science 2013 342 (6161): 979-83 Pubmed

Soldner F, Laganière J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Myers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu BJ, Meng X, Urnov FD, Rebar EJ, Gregory PD, Zhang HS, Jaenisch R. Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations. Cell 2011 146(2):318-31. Pubmed

Tau

Khurana V*, Merlo P*, Duboff B, Sharp KA, Fulga TA, Campbell S, Gotz J and Feany MB. A neuroprotective role for the DNA damage checkpoint in tauopathy. Aging Cell 2012 11(2): 360-62 PDF *Equal contribution

Khurana V*, Elson-Schwab I,* Fulga TA*, Sharp KA, Mulkearns E, Loewen CA, Scherzer CR, Tyynelä J and Feany MB. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genetics 2010 6(7): e1001026. doi:10.1371/journal.pgen.1001026 PDF *Equal contribution

Fulga TA, Elson-Schwab I, Khurana V, Michelle L Steinhilb, Soires TL, Hyman BT, Feany MB. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nature Cell Biology 2007 9:139-148.Pubmed

Khurana V, Lu Y, Steinhilb ML, Oldham S, Shulman JM, Feany MB. TOR-mediated cell- cycle activation causes neurodegeneration in a Drosophila tauopathy model. Current Biology 2006 16: 231-241.PDF

Ataxins

Khurana V*º, Chung CY*, Peng J*, Auluck PK, Tardiff DF, Fanning S, Bartels T, Koeva M, Benyamini   H, Lou Y, Nutter-Upham A, Tuncbag N, Baru V, Freyzon Y, Costanzo M, San-Luis B, Schöndorf DC, Barrasa MI, Caraveo G, Ehsani S, Sanjana N, Zhong Q, Gasser T, Vidal M, Deleidi M, Boone C, Berger Bº, Fraenkel Eº, Lindquist S. Genome-scale molecular networks link neurodegenerative disease genes to alpha-synuclein through specific molecular pathways. Cell Systems 2017 4(2): 157-70. PDF  *Equal contribution ºCo-corresponding authors

Khurana V, Fulga TA, Feany MB. Senseless makes sense for spinocerebellar ataxia-1. Nature Neuroscience 2005 8: 1422-1424. PDF

Systems Biology

Khurana V*º, Chung CY*, Peng J*, Auluck PK, Tardiff DF, Fanning S, Bartels T, Koeva M, Benyamini   H, Lou Y, Nutter-Upham A, Tuncbag N, Baru V, Freyzon Y, Costanzo M, San-Luis B, Schöndorf DC, Barrasa MI, Caraveo G, Ehsani S, Sanjana N, Zhong Q, Gasser T, Vidal M, Deleidi M, Boone C, Berger Bº, Fraenkel Eº, Lindquist S. Genome-scale molecular networks link neurodegenerative disease genes to alpha-synuclein through specific molecular pathways. Cell Systems 2017 4(2): 157-70. PDF  *Equal contribution ºCo-corresponding authors

Sidhi N, Yi, S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F Peng J Weile J, Karras GI,Kamburov A, Krykbaeva I, Tucker G, Khurana V, Sharma A, Liu Y-Y, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh, JM, Shah, AA, Yang X, Stoyanova A, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Charloteaux B, Berger B, Hill DE, Barabási A-L, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M. Widespread perturbation of disease-specific macromolecular interactions in human genetic disorders. Cell 2015 161(3):647-60.

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